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| Drug Class | Examples | Indications | Key Notes | |------------|----------|-------------|------------| | SSRIs | Fluoxetine, paroxetine, sertraline | Generalized anxiety, aggression, compulsive disorders | Long onset (4–8 weeks); first-line for chronic use | | Tricyclics (TCAs) | Clomipramine, amitriptyline | Separation anxiety, compulsive disorders, urine spraying | Sedation, anticholinergic effects | | Benzodiazepines | Alprazolam, diazepam | Panic, phobias (noise), acute anxiety | Short-acting, risk of disinhibition aggression, dependence | | Azapirones | Buspirone | Chronic anxiety, feline urine marking (not sedating) | No withdrawal, but slow onset | | Alpha-2 agonists | Dexmedetomidine (oral gel in cats) | Acute fear/noise phobia | Significant sedation | | Gabapentin/Trazodone | – | Pre-vet visit anxiolysis, post-surgical calming, chronic pain-associated anxiety | Excellent safety profile | Given the nature of the keywords, it is