For the first time all season, they weren’t just competing.
He fails. Amber dies.
A former plastic surgeon seeking a fresh start. House MD - Season 4
Then comes Wilson's Heart (S4E16). The dying passenger is revealed to be (Anne Dudek), the ruthless "Cutthroat Bitch" who is now dating House’s best friend, Dr. James Wilson. House must save Amber knowing it will destroy Wilson if he fails. He fails. For the first time all season, they weren’t just competing