: Standard NTSC/USA versions are roughly 4.2 GB. Compressed formats like .7z or .chd can significantly reduce this size, with some community versions reaching approximately 433 MB .
Turn off "Bloom" and "Motion Blur" in the AetherSX2 shader settings. Also, reduce the upscale multiplier to Native. Resident Evil 4 Aethersx2 Highly Compressed
To help you get the best performance on your specific hardware, here are some guides on optimizing AetherSX2 for Resident Evil 4: : Standard NTSC/USA versions are roughly 4