He groaned. This is the part of the story where most people give up.
is a polished, paid version of Wine. It offers a much smoother experience and is more likely to work on newer Apple Silicon (M1/M2/M3) Macs. Open CrossOver and click "Install a Windows Application." bioedit download mac
BioEdit (by Tom Hall) is a classic, user-friendly sequence alignment and analysis tool, but it was never released for macOS. It requires Windows or Windows emulation. He groaned