An organic chemistry approach changes the question. Instead of asking "What is the next intermediate in glycolysis?" it asks "Why does this reaction require a decarboxylation step?" or "What type of nucleophilic attack is occurring here?" For example, consider the isomerization of glucose-6-phosphate to fructose-6-phosphate. A standard text might list the enzyme (phosphoglucose isomerase) and move on. An organic chemistry PDF highlights the —a classic tautomerization mechanism that any second-semester o-chem student would recognize. Suddenly, the pathway becomes logical rather than arbitrary.
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