Plug in the USB cable. A red LED should light up. If it’s the "hot" variant, a green LED indicates 3.3V mode is active.
The NeoProgrammer software and the 22010 hardware have a thriving community: neoprogrammer 22010 hot
Setting up is straightforward. You can find downloads on community forums like or specialized archives like MichaTronic Install Drivers: Drivers/CH341A subdirectory before plugging in your hardware. Detect the IC: Plug in the USB cable